STMN 1

Role in the organism:

Statmin 1 is an intracellular signaling protein - a protein that responds to the activation of receptors on the surface of the cell membrane and transmits impulse to transcription factors in the nucleus, so that it participates in the regulation of expression of certain genes. The name of the protein itself comes from the greek word transfer, relay. Statmin is very expressive and probably has many functions, including control of cell proliferation. This protein must be phosphorylated to convert to active form.

Role in the disorder (state):

Statmin 1 is also known as leukemia-associated protein because it is often present, in phosphorylated form, in childhood leukemias. In these cases, there is a constant activity of certain components of the signaling pathway, so that statmin remains constantly in its phosphorylated form and constantly sends impulses to nuclear transcription factors.