F7, F10

Role in the organism:

Coagulation factors VII and X are components of the cascade process of blood coagulation. Blood coagulation is initiated either by trauma or damage to blood vessels and culminates in the conversion of the circulating protein fibrinogen into its fibrin derivative, a substance of blood clots. Factor X plays a central role in the cascade process by converting the inactive prothrombin polypeptide into the active enzyme thrombin, which then acts on fibrinogen. Factor VII is one of the proteins that activate factor X.

Role in the disorder (state):

Mutations in any of these genes result in prolonged coagulation time, which is manifested by prolonged bleeding. The lack of factor X varies in the severity of the symptoms, which occur regardless of how coagulation is initiated. In contrast, factor VII deficiency affects an unusual clotting pathway, which is initiated by trauma but not by contact with surfaces such as glass.